李辉   教授   博士生导师   

中国地质大学（武汉） 材料与化学学院              

湖北省武汉市东湖新技术开发区锦程街68号

Email：lihui-chem@cug.edu.cn or li_hui@cug.edu.cn

ORCID：0000-0001-7849-9735

教育与研究经历

2014年1月-2017年8月      博士后      加州大学圣芭芭拉分校

                                      导师：Kevin W. Plaxco教授

                                      获瑞士国家研究基金博士后奖学金

2013年6月-2013年12月     博士后      瑞士伯尔尼大学    导师：Silvio Decurtins教授

2009年10月-2013年5月     博  士      瑞士伯尔尼大学    导师：Silvio Decurtins教授

                                      获玛丽居里全额奖学金Marie Curie fellowship    

2010年10月-2010年12月    短期访问    西班牙马德里康普顿斯大学

                                      导师：Nazario Martin教授

2006年9月-2009年6月      硕士（保送）湘潭大学高分子化学与物理

                                      导师：谭松庭教授

2002年9月-2006年6月      学   士    湘潭大学高分子材料与工程

学术成果

长期致力于开发和研究新型电化学生物传感器，将其应用于复杂生物体系（如血液及动物体内）的临床药物以及疾病标志物的快速、实时、有效检测，实现对疾病的早期诊断，达到早诊断早治疗的目的。迄今为止，已在J. Am. Chem. Soc., Angew. Chem. Int. Ed.，Nanoscale, Analytical Chemistry, Macromolecules等国际核心期刊上发表SCI论文20余篇，参与撰写英文著作1部 （springer出版社），论文SCI引用400余次。申请美国发明专利两项。

获奖与荣誉

1.         瑞士自然科学基金“青年博士后奖学金”（2014-2015）

2.         欧盟“玛丽居里”奖学金（2009-2013）

参与主持的项目与课题

1.         国家自然科学基金青年基金1项，2018年-2020年，项目名称为：基于比率法的电化学生物传感器用于全血样本中小分子药物的精准、实时检测

2.         基于给受体有机半导体材料的设计，合成与应用（欧盟玛丽居里初期网络培训基金，FP7）

3.         具有实时监控，微型化，多功能化的生物传感器的研发与应用（美国NIH基金）

代表性成果

1.        Hui Li, Philippe Dauphin-Ducharme, Gabriel Ortega, Kevin W. Plaxco*. Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood, J. Am. Chem. Soc., 2017, 139, 11207-11213

2.        Hui Li, Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Claire Tran, Philip A. Vieira, Shaoguang Li, Christina Shin, Jacob Somerson, Tod E. Kippin, and Kevin W. Plaxco*. A biomimetic surface greatly improves the in-vivo performance of electrochemical aptamer-based sensors. Angew. Chem. Int. Ed., 2017, 56, 7492-7495

3.        Hui Li, Netzahualcóyotl Arroyo-Currás, Di Kang, Francesco Riccic, and Kevin W. Plaxco*. Dual-reporter drift correction to enhance the performance of electrochemical aptamer-based sensors in whole blood. J. Am. Chem. Soc., 2016, 138, 15809-15812

4.        Hui Li, Jacob Somerson, Fan Xia,* and Kevin W. Plaxco*. Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk. Anal. Chem., 2018, 90, 10641−10645.

5.        Gabriel Ortega, Martin Kurnik, Philippe Dauphin‐Ducharme, Hui Li, Netzahualcóyotl Arroyo‐Currás, Amanda Caceres, Kevin W. Plaxco*, Surface Attachment Enhances the Thermodynamic Stability of Protein L. Angew. Chem. Int. Ed., 2019, 58, 1714 –1718.

6.        Martin Kurnik, Gabriel Ortega, Philippe Dauphin-Ducharme, Hui Li, Amanda Caceres, Kevin W. Plaxco*. Quantitative measurements of protein-surface interaction thermodynamics; Proc. Natl. Acad. Sci. USA, 2018, 115, 8352-8357.

7.        Zhihai Li, ^# Hui Li, ^# Songjie Chen, Toni Froehlich, Chenyi Yi, Christian Schönenberger, Michel Calame, Silvio Decurtins, Shi-Xia Liu*, Eric Borguet*. Regulating a Benzodifuran Single Molecule Redox Switch via Electrochemical Gating and Optimization of Molecule/Electrode Coupling, J. Am. Chem. Soc., 2014, 136, 8867-8870 (^#共同一作)

8.        Wenjing Hong, Hui Li, Shi-Xia Liu*, Yongchun Fu, Jianfeng Li, Veerabhadrarao Kaliginedi, Silvio Decurtins, and Thomas Wandlowski*, Trimethylsilyl-Terminated Oligo(phenylene ethynylene)s: An Approach to Single-Molecule Junctions with Covalent Au−C σ-Bonds. J. Am. Chem. Soc., 2012, 134, 19425-19431.

9.        Hui Li, Peng Jiang, Chenyi Yi, Chen Li, Shi-Xia Liu*, Songting Tan*, Bin Zhao, Jörg Braun, Wolfgang Meier, Thomas Wandlowski and Silvio Decurtins, Benzodifuran-based pi-Conjugated Copolymers for Bulk Heterojunction Solar Cells. Macromolecules, 2010, 43, 8058-8062

10.    An Xiang^#, Hui Li^#, Songjie Chen, Shi-Xia Liu*, Silvio Decurtins, Meilin Bai, Shimin Hou and Jianhui Liao*. Electronic transport in benzodifuran single-molecule transistors, Nanoscale, 2015, 7, 7665-7673 (^#共同一作)

11.    Hui Li, Chenyi Yi, Sofiane Moussi, Shi-Xia Liu*, Claude Daul, Michael Grätzel*, and Silvio Decurtins. Benzo[1,2-b:4,5-b’]difuran-Based Sensitizers for Dye-Sensitized Solar Cells, RSC Adv., 2013, 3, 19798-19801

12.    Hui Li, Jie Ding, Songjie Chen, Christoph Beyer, Shi-Xia Liu*, Hans-Achim Wagenknecht, Andreas Hauser* and Silvio Decurtins, Synthesis, Redox and Photophysical Properties of Benzodifuran-Spiropyran Ensembles, Chem. Eur. J., 2013, 19, 6459-6466

13.    Hui Li, Christina Schubert, Rubén D. Costa, Andrea La Rosa, Jürg Thüring, Shi-Xia Liu*, Chenyi Yi, Salvatore Filippone, Nazario Martín, Silvio Decurtins, Timothy Clark and Dirk M. Guldi*. Probing Charge Transfer in Benzodifuran-C60 Electron Donor-Acceptor Conjugates – Ground and Excited State Assays, ChemPhsyChem, 2013, 14, 2910-2919

14.    Yves Aeschi,^# Hui Li,^# Zhencai Cao, Songjie Chen, Anneliese Amacher, Nathalie Bieri, Bilâl Özen, Juerg Hauser, Silvio Decurtins, Songting Tan, Shi-Xia Liu*. Directed metalation cascade to access highly functionalized thieno[2,3-f][1]benzofuran, Org. Lett., 2013, 15, 5586–5589 (^#共同一作)

15.    Hui Li, Peng Tang, Yan Zhao, Shi-Xia Liu*, Yves Aeschi, Lijun Deng, Jörg Braun, Bin Zhao, Yunqi Liu, Songting Tan, Wolfgang Meier, Silvio Decurtins, Benzodifuran- Containing Well-Defined pi-Conjugated Polymers for Photovoltaic Cells. J. Polym. Sci. A: Polym. Chem., 2012, 50, 2935-2943

撰写英文著作：

Hui Li*, Shaoguang Li, Fan Xia. Biosensors based on Sandwich Assays: Chapter 4- Electrochemical Sandwich Assay for protein detection, Springer, 2018, 01, 10, Page 47-68

申请美国专利两项：

1. Hui Li, Netzahualcoyotl Arroyo, Di Kang and Kevin Plaxco. Dual-Label Electrochemical Sensors with Drift Correction, PCT/US17/053228.

2. Hui Li, Philippe Dauphin-Ducharme, Gabriel Ortega, Kevin W. Plaxco. Calibration-free, drift-free electrochemical sensors employing difference in electron transfer kinetics, UCSB023P, 2017-248.