Professor Xiaoding Lou
Faculty of Materials Science and Chemistry
China University of Geosciences
68 Jincheng Street, Wuhan East Lake,
New Technology Development Zone,
Wuhan City, Hubei Province, China
E-mail: louxiaoding@cug.edu.cn
Education and Work Experience
Professor (2017-now): Faculty of Materials Science and Chemistry, China University of Geosciences, China
Associate/Assistant Professor (2013-2016): Huazhong University of Science and Technology, China
Visiting scholar (2016.4-10): University of California, Santa Barbara, USA (Prof. Alan J. Heeger’s group)
Research Associate (2012-2013): Hong Kong University of Science and Technology, Hong Kong (Prof. Ben Zhong Tang’s group)
PhD (2007-2012): College of Chemistry and Molecular Sciences, Wuhan University, China (Prof. Zhen Li’s group)
BS (2003-2007): Hubei Engineering University, China
Research Summary
Her scientific interest is focused on chemical and biosensor field. She designs a series of real-time and in-situ analytical assays, based on the group behavior of the signal units not like the traditional behavior of single signal unit.
She has published 67 SCI papers (42 of them IF>6). Her works have been cited for more than 1400 times. There is one ESI highly cited paper, and 4 papers have been cited for more than 100 times.
In recent five years, as the first author or the corresponding author, she has published 31 papers, including Chem Soc Rev (1), Chem Sci (2), Anal Chem (9), Adv Mater (1), NPG Asia Mater (1), Small (2).
Projects Undertook
2018-2020 National Natural Science Foundation of China, 21722507, Host
2018-2020 Natural Science Foundation of Zhejiang Province, LY18B050002, Host
2016-2019 National Natural Science Foundation of China, 21574048, Host
2015-2017 National Natural Science Foundation of China, 21405054, Host
2017-2019 National Key R&D Program of China, 2016YFF0100800, Host of subsidiary subject
Selected Publications
1. Duan, Ruixue, Lou, Xiaoding(*) and Fan Xia(*). The development of nanostructure assisted isothermal amplification in biosensors, Chemical Society Reviews, 2016, 45, 1738-1749. IF=38.618; Times Cited: 22
2. Gao, Pengcheng, Hu, Lintong, Liu, Nannan, Yang, Zekun, Lou, Xiaoding(*), Zhai, Tianyou(*), Li, Huiqiao, and Xia, Fan(*), Functional “janus” annulus in confined channel, Advanced Materials, 2016, 28, 460-465. IF=19.791; Times Cited: 4
3. Cheng, Yong, Sun, Chunli, Ou, Xiaowen, Liu, Bifeng, Lou, Xiaoding(*), and Xia, Fan(*), Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells. Chemical Science, 2017, 8, 4571-4578. IF=8.668; Times Cited: 1
4. Xu, Xuemei, Zhao, Wei, Gao, Pengcheng, Li, Huiqing, Feng, Guang, Zhao, Zujin, Lou, Xiaoding(*), Coordination of the electrical and optical signals revealing nanochannels with an “onion-like” gating mechanism and its sensing application, NPG Asia Materials, 2016, 2016, 8, e234. IF=9.157; Times Cited: 6
5. Chang, Zhengfeng, Jing, Lingmin, Chen, Bin, Zhang, Mengshi, Liu, Junjie, Ye, Yanchun, Lou, Xiaoding(*), Zhao, Zujin(*), Liu, Bin(*), Wang, Jinliang(*), Tang, Ben Zhong, Rational design of asymmetric red fluorescent probes for live cell imaging with high AIE effect and large two-photon absorption cross section by tuneable terminal group, Chemical Science, 2016, 7, 4527-4536. IF=8.668; Times Cited: 17
6. Zi Long(#), Shenshan Zhan(#), Pengcheng Gao, Yongqian Wang, Xiaoding Lou(*), Fan Xia(*), Recent advances in solid nano-pore/channel analysis. Analytical Chemistry, 2017, Accept, DOI: 10.1021/acs.analchem.7b04737, IF=6.320; Times Cited: 0
7. Jia, Yongmei(#), Gao, Pengcheng(#), Zhuang, Yuan(#), Miao, Mao, Lou, Xiaoding(*), Xia, Fan, Facile probe design: fluorescent amphiphilic nucleic acid probes without quencher providing telomerase activity Imaging inside living cells, Analytical Chemistry, 2016, 88, 6621-6626. IF=6.320; Times Cited: 8
8. Zhang, Xiaojin, Lou, Xiaoding(*), Xia, Fan(*), Advances in the detection of telomerase activity using isothermal amplification, Theranostics, 2017, 7, 1847-1862. IF=8.712; Times Cited: 2
9. Ou, Xiaowen, Lou, Xiaoding(*), Xia, Fan(*), A highly sensitive DNA-AIEgen-based “turn-on” fluorescence chemosensor for amplification analysis of Hg2+ ions in real samples and living cells, Science China Chemistry, 2017, 60, 663-669. IF=4.132; Times Cited: 0
10. Min, Xuehong, Xia, Lei, Zhuang, Yuan, Wang, Xudong, Du, Jie, Zhang, Xiaojin, Lou, Xiaoding(*), Xia, Fan(*), An AIEgens and exonuclease III aided quadratic amplification assay for detecting and cellular imaging of telomerase activity, Science Bulletin, 2017, 62, 997-1003, IF=4.000; Times Cited: 0
11. Zhuang, Yuan(#), Shang, Chunli(#), Lou, Xiaoding(*), Xia, Fan(*), Construction of AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity, Analytical Chemistry, 2017, 89, 2073-2079. IF=6.320; Times Cited: 1
12. Ou, Xiaowen, Wei, Benmei, Zhang, Zhenyu, Zhang, Mengshi, Zhuang, Yuan, Gao, Pengcheng(*), Lou, Xiaoding(*), Xia, Fan, Tang, Ben Zhong, Detection of UVA/UVC-induced damage of p53 fragment by rolling circle amplification with AIEgens, Analyst, 2016, 141,4394-4399. IF=3.885; Times Cited: 0
13. Ou, Xiaowen, Hong, Fan, Zhang, Zhenyu, Cheng, Yong, Zhao, Zujin, Gao, Pengcheng, Lou, Xiaoding(*), Xia, Fan, Wang, Shutao, A highly sensitive and facile graphene oxide-based nucleic acid probe: label-free detection of telomerase activity in cancer patient's urine using AIEgens, Biosensors and Bioelectronics, 2016, 141, 4394-4399. IF=7.780; Times Cited: 4
14. Liu, Nannan(#), Li, Cao(#), Zhang, Tianchi, Hou, Ruizuo, Xiong, Zhiping, Li, Zeyong, Wei, Benmei, Yang, Zekun, Gao, Pengcheng(*), Lou, Xiaoding(*), Zhang, Xianzheng, Guo, Wei, Xia, Fan, Fabrication of "plug and play" channels with dual responses by host-guest interactions, Small, 2017, 13(1600287):1~6. IF=8.643; Times Cited: 1
15. Lou, Xiaoding, Zhao, Zujin(*), Tang, Ben Zhong(*), Organic dots based on AIEgens for two-photon fluorescence bioimaging, Small, 2016, 12, 6430-6450. IF=8.643; Times Cited: 7
16. Lou, Xiaoding, Zhang, Mengshi, Zhao, Zujin, Min, Xuehong, Hakeem, Abdul, Huang, Fujian, Gao, Pengcheng, Xia, Fan (*), Tang, Ben Zhong, A photostable AIE fluorogen for lysosome-targetable imaging of living cells, Journal of Materials Chemistry B, 2016, 4, 5412-5417. IF= 4.543; Times Cited: 2
17. Cheng, Yong, Huang, Fujian, Min, Xuehong, Gao, Pengcheng, Zhang, Tianchi, Li, Xinchun, Liu, Bifeng, Hong, Yuning, Lou, Xiaoding(*), Xia, Fan(*), Protease-responsive prodrug with aggregation-induced emission probe for controlled drug delivery and drug release tracking in living cells, Analytical Chemistry, 2016, 88, 8913-8919. IF=6.320; Times Cited: 7
18. Min, Xuehong(#), Zhang, Mengshi(#), Huang, Fujian, Lou, Xiaoding(*), Xia, Fan, Live cell microRNA imaging using exonuclease III-aided recycling amplification based on AIEgens, ACS Applied Materials & Interfaces, 2016, 8, 8998-9003. IF=7.504; Times Cited: 11
19. Zhuang, Yuan(#), Xu, Qi(#), Huang, Fujian, Gao, Pengcheng, Zhao, Zujin, Lou, Xiaoding(*), Xia, Fan, Ratiometric fluorescent bioprobe for highly reproducible detection of telomerase in bloody urines of bladder cancer patients, ACS Sensors, 2016, 1, 572-578; Times Cited: 11
20. Xu, Xuemei, Hou, Ruizuo, Gao, Pengcheng, Miao, Mao, Lou, Xiaoding(*), Liu, Bifeng, Xia, Fan, Highly robust nanopore-based dual-signal-output ion detection system for achieving three successive calibration curves, Analytical Chemistry, 2016, 88, 2386-2391. IF=6.320; Times Cited: 3
21. Zhuang, Yuan, Huang, Fujian, Xu, Qi, Zhang, Mengshi, Lou, Xiaoding(*), Xia, Fan, Facile, Fast-responsive and photostable imaging of telomerase activity in living cells with a fluorescence turn-on manner, Analytical Chemistry, 2016, 88, 3289-3294. IF=6.320; Times Cited: 18
22. Hakeem, Abdul, Zahid, Fouzia, Duan, Ruixue, Asif, Muhammad, Zhang, Tianchi, Zhang, Zhenyu, Cheng, Yong, Lou, Xiaoding(*), Xia, Fan(*), Cellulose conjugated FITC-labelled mesoporous silica nanoparticles: intracellular accumulation and stimuli responsive doxorubicin release, Nanoscale, 2016, 8, 5089-5097. IF=7.367; Times Cited: 10
23. Liu, Nannan, Hou, Ruizuo, Gao, Pengcheng, Lou, Xiaoding(*), Fan Xia, Sensitive Zn2+ sensor based on biofunctionalized nanopores by combination of DNAzyme and DNA supersandwich structures, Analyst, 2016, 141, 3626-3629. IF=3.885; Times Cited: 7
24. Zhuang, Yuan, Zhang Mengshi, Chen Bin, Duan Ruixue, Min Xuehong, Zhang Zhenyu, Zheng Fuxin, Liang Huageng, Zhao Zujin, Lou Xiaoding(*), Xia Fan, Quencher group induced high specificity detection of telomerase in clear and bloody urines by AIEgens, Analytical Chemistry, 2015, 87, 9487-9493. IF=6.320; Times Cited: 22
25. Lou, Xiaoding(#), Zhuang, Yuan(#), Zuo, Xiaolei(#), Jia, Yongmei, Hong, Yuning, Min, Xuehong, Zhang, Zhenyu, Xu, Xuemei, Liu, Nannan, Xia, Fan(*), Tang, Ben Zhong, Real-time, quantitative lighting-up detection of telomerase in urines of bladder cancer patients by AIEgens, Analytical Chemistry, 2015, 87, 6822-6827. IF=6.320; Times Cited: 39
26. Min, Xuehong(#), Zhuang, Yuan(#), Zhang, Zhenyu, Jia, Yongmei, Zheng, Fuxin, Cheng, Yong, Tang, Ben Zhong, Lou, Xiaoding(*), Xia, Fan, Lab in a tube: sensitive detection of microRNAs in urines samples from bladder cancer patients using a single-label DNA probe with AIEgens, ACS Applied Materials & Interfaces, 2015, 7, 16813-16818. IF=7.504; Times Cited: 14
27. Lou, Xiaoding, Zhao, Zujin, Hong, Yuning, Dong, Chao, Min, Xuehong, Zhuang, Yuan, Xu, Xuemei, Jia, Yongmei, Xia, Fan(*), Tang, Ben Zhong(*), A new turn-on chemosensor for bio-thiols based on the nanoaggregates of a tetraphenylethene-coumarin fluorophore, Nanoscale, 2014, 6, 14691-14696. IF=7.367; Times Cited: 26
28. Lou, Xiaoding, Hong, Yuning, Chen, Sijie, Leung, Chris Wai Tung, Zhao Na, Bo, Situ, Lam, Jacky Wing Yip Lam, Tang, Ben Zhong(*), A selective glutathione probe based on AIE fluorogen and its application in enzymatic activity assay, Scientific Reports, 2014, 4, 4272. IF=4.259; Times Cited: 28
29. Hakeem, Abdul, Duan, Ruixue, Zahid, Fouzia, Dong, Chao, Wang, Boya, Hong, Fan, Ou, Xiaowen, Jia, Yongmei, Lou, Xiaoding(*), Xia, Fan(*), Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan, Chemical Communications, 2014, 50, 13268-13271. IF=6.319; Times Cited: 36
30. Jia, Yongmei(#), Zuo, Xiaolei(#), Lou, Xiaoding(#), Miao, Mao, Cheng, Yong, Min, Xuehong, Li, Xinchun, Xia, Fan(*), Rational designed bipolar, conjugated polymer-DNA composite beacon for the sensitive detection of proteins and ions, Analytical Chemistry, 2015, 87, 3890-3894. IF=6.320; Times Cited: 21