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1.Wei Guo, Fan Hong, Nannan Liu, Jiayu Huang , Boya Wang, Ruixue Duan, Xiaoding Lou, Fan Xia*. Target-Specific 3D DNA Gatekeepers for Biomimetic Nanopores, Advance Materials, 2015, 27, 2090.

2.Yuan Zhuang, Mengshi Zhang, Bin Chen, Ruixue Duan, Xuehong Min, Zhenyu Zhang, Fuxin Zheng, Huageng Liang, Zujin Zhao, Xiaoding Lou*, Fan Xia. Quencher Group Induced High Specificity Detection of Telomerase in Clear and Bloody Urines by AIEgens, Analytical Chemistry, 2015, 87, 9487.

3. Xiaoding Lou#, Yuan Zhuang#, Xiaolei Zuo#, Yongmei Jia, Yuning Hong, Xuehong Min, Zhenyu Zhang, Xuemei Xu, Nannan Liu, Fan Xia*. Ben Zhong Tang. Real-Time, Quantitative Lighting-up Detection of Telomerase in Urines of Bladder Cancer Patients by AIEgens, Analytical Chemistry, 2015, 87, 6822.

4. Xuehong Min#, Yuan Zhuang#, Zhenyu Zhang, Yongmei Jia, Fuxin Zheng, Yong Cheng, Ben Zhong Tang, Xiaoding Lou*, Fan Xia, Lab in a Tube: Sensitive Detection of MicroRNAs in Urine Samples from Bladder Cancer Patients Using a Single-label DNA Probe with AIEgens, ACS Applied Materials & Interfaces, 2015, 7, 16813.

5. Yongmei Jia#, Xiaolei Zuo#, Xiaoding Lou#, Mao Miao, Yong Cheng, Xuehong Min, Xinchun Li, Fan Xia*, Rational designed bipolar, conjugated polymer-DNA composite beacon for the sensitive detection of proteins and ions, Analytical Chemistry, 2015, 87, 3890.

6. Yi Deng, Xin Wang, Feng Xue, Lei Zheng, Jian Liu, Feng Yan, Fan Xia*, Wei Chen *, Ultrasensitive and rapid screening of mercury(II) ions by dual labeling colorimetric method in aqueous samples and applications in mercury-poisoned animal tissues, Analytica Chimica Acta, 2015, 868, 45-52.

7.Tianchi Zhang‡, Chunli Shang‡, Ruixue Duan, Abdul Hakeem, Zhenyu Zhang, Xiaoding Lou and Fan Xia*, Polar organic solvents accelerate the rate of DNA strand replacement reaction, Analyst, 2015, 140, 2023-2028.

8. Ruixue Duan‡, Boya Wang‡, Fan Hong, Tianchi Zhang, Yongmei Jia, Jiayu Huang, Abdul Hakeem, Nannan Liu, Xiaoding Lou, Fan Xia*, Real-time monitoring of enzyme-free strand displacement cascades by colorimetric assays, Nanoscale, 2015, 7, 5719-5725.

9. Benmei Wei, Nannan Liu, Juntao Zhang, Xiaowen Ou, Ruixue Duan, Zekun Yang, Xiaoding Lou, and Fan Xia*, Regulation of DNA Self-Assembly and DNA Hybridization by Chiral Molecules with Corresponding Biosensor Applications, Anal. Chem. 2015, 87, 4, 2058–2062.

10. Juntao Zhang, Nannan Liu, Benmei Wei, Xiaowen Ou, Xuemei Xu, Xiaoding Loua, Fan Xia*,  The opposite gating behaviors of solid-state nanochannels modified with long and short polymer chains, Chemical Communications, 2015, 51, 10146-10149.


1. Juwen Shen, Yuebin Li, Haoshuang Gu, Fan Xia*, Xiaolei Zuo*, Recent Development of Sandwich Assay Based on the Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions, Chemical Reviews, 2014, 114, 7631.

2. Ruixue Duan, Xiaolei Zuo, Shutao Wang, Xiyun Quan, Dongliang Chen, Zhifei Chen, Lei Jiang, Chunhai Fan, Fan Xia*, Quadratic isothermal amplification for the detection of microRNA, Nature Protocols, 2014, 9, 597.

3. Xiaoding Lou, Zujin Zhao, Yuning Hong, Chao Dong, Xuehong Min, Yuan Zhuang, Xuemei Xu, Yongmei Jia, Fan Xia*, Ben Zhong Tang*. A new turn-on chemosensor for bio-thiols based on the nanoaggregates of a tetraphenylethene-coumarin fluorophore, Nanoscale, 2014, 6, 14691.

4. Abdul Hakeem, Ruixue Duan, Fouzia Zahid, Chao Dong, Boya Wang, Fan Hong, Xiaowen Ou, Yongmei Jia, Xiaoding Lou*,Fan Xia*. Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan, Chemical Communications, 2014, 50, 13268.

5. Di kang‡, Ruixue Duan‡, Yerpeng Tan‡, Fan Hong, Boya Wang, Zhifei Chen, Shaofang Xu, Xiaoding Lou, Wei Wei*, Bernard Yurked, Fan Xia*, Speeding up the self-assembly of a DNA nanodevice using a variety of polar solvents, Nanoscale, 2014, 6, 14153-14157.

6. Ruixue Duan, Boya Wang, Tianchi Zhang, Zhenyu Zhang, Shaofang Xu, Zhifei Chen, Xiaoding Lou, and Fan Xia* , Sensitive and Bidirectional Detection of Urine Telomerase Based on the Four Detection-Color States of Difunctional Gold Nanoparticle Probe, Anal. Chem. 2014, 86, 19, 9781–9785.

7. Yongmei Jia*, Benmei Wei*, Ruixue Duan, Ying Zhang, Boya Wang, Abdul Hakeem, Nannan Liu, Xiaowen Ou, Shaofang Xu, Zhifei Chen, Xiaoding Lou, Fan Xia, Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation, Scientific Reports, 2014, 4, 5929.


1. Ruixue Duan, Xiaolei Zuo, Shutao Wang, Xiyun Quan, Dongliang Chen, Zhifei Chen, Lei Jiang, Chunhai Fan, Fan Xia*, Lab in a Tube: Ultrasensitive Detection of MicroRNAs at the Single-Cell Level and in Breast Cancer Patients Using Quadratic Isothermal Amplification, Journal of the American Chemical Society, 2013, 135, 4604.

2. Nannan Liu, Yanan Jiang, Yahong Zhou, Fan Xia*, Wei Guo*,. Lei Jiang, Two-Way Nanopore Sensing of Sequence-Specific Oligonucleotides and Small-Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures, Angewandte Chemie-International Edition, 2013, 52, 2007.

3.Yongmei Jia, Ruixue Duan, Fan Hong, Boya Wang, Nannan Liu and Fan Xia*, Electrochemical biocomputing: a new class of molecular-electronic logic devices, Soft Matt. 2013, 9, 6571.

4. Ruixue Duan, Fan Xia, and Lei Jiang*, Constructing Tunable Nanopores and Their Application in Drug Delivery, ACS Nano 2013, 7, 10, 8344–8349.


1. Yanan Jiang, Nannan Liu, Wei Guo*, Fan Xia*, Lei Jiang, Highly-Efficient Gating of Solid-State Nanochannels by DNA Supersandwich Structure Containing ATP Aptamers: A Nanofluidic IMPLICATION Logic Device, Journal of the American Chemical Society, 2012, 134, 15395.

2. Di Kang, Ryan J White, Fan Xia*, Xiaolei Zuo*, Alexis Vallée-Bélisle, Kevin W Plaxco*, DNA biomolecular-electronic encoder and decoder devices constructed by multiplex biosensors, NPG Asia Materials, 2012, 4, 15197.

3. Alexis Vallée-Bélisle, Francesco Ricci, Takanori Uzawa, Fan Xia, Kevin W. Plaxco*, Bioelectrochemical Switches for the Quantitative Detection of Antibodies Directly in Whole Blood, J. Am. Chem. Soc., 2012, 134, 15197.


1. Hongwei Xia, Fan Xia*, Yecang Tang, Wei Guo, Xu Hou, Li Chen, Yi Hou, Guangzhao Zhang, Lei Jiang*, Tuning Surface Wettability through Supramolecular Interactions, Soft Matt., 2011, 7, 1638.

2. Xiaolei Zuo, Fan Xia, Adriana Patterson, H. Tom Soh, Yi Xiao,* Kevin W. Plaxco*, Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling, ChemBioChem., 2011, 12, 2745.

3. Liuxuan Cao, Wei Guo*, Wen Ma, Lin Wang, Fan Xia, Shutao Wang, Yugang Wang*, Lei Jiang, Daoben Zhu, Towards understanding the nanofluidic reverse electrodialysis system: well matched charge selectivity and ionic composition, Energ. Environ. Sci., 2011, 4, 2259.


1. Fan Xia, Xiaolei Zuo, Renqiang Yang, et al. On the Binding of Cationic, Water-Soluble Conjugated Polymer to DNA: Electrostatic and Hydrophobic Interactions, J. Am. Chem. Soc., 2010, 132, 1252.

2. Fan Xia, Xiaolei Zuo, Yi Xiao, et al. Label-free, Dual-analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic Gates, J. Am. Chem. Soc., 2010, 132, 8557.

3. Fan Xia, Ryan White, Xiaolei Zuo, et al. An electrochemical supersandwich structure assay for sensitive and selective DNA detection in serum, J. Am. Chem. Soc., 2010, 132, 14346.

4. Fan Xia#, Xiaolei Zuo#, Renqiang Yang , Alan J. Heegera*, Kevin W. Plaxco*, et al, Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes, PNAS, 2010, 107, 10837-10841.


1. Fan Xia, Ying Zhu, Lin Feng*, Lei Jiang, Smart responsive surfaces switching between super-hydrophobicity and super-hydrophilicity, Soft Matt., 2009, 5, 275.

2. Xu Hou, Wei Guo, Fan Xia, et al. A Biomimetic Potassium Responsive Nanochannel: G-Quadruplex DNA Conformational Switching in a Synthetic Nanopore, J. Am. Chem. Soc., 2009, 131, 7800.

3. Li Chen, Mingjie Liu, Hao Bai, Peipei Chen, Fan Xia, et al. Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography, J. Am. Chem. Soc., 2009, 131, 10467.


1. Fan Xia, Wei Guo, Youdong Mao, Yugang Wang,* Lei Jiang* et al. Gating of single synthetic nanopores by proton-driven DNA molecular motors, J. Am. Chem. Soc., 2008, 130, 8345.

2. Fan Xia, Lei Jiang*, Bio-inspired smart multi-scale interfacial materials, Adv. Mater., 2008, 20, 2842.

3. Lin Feng, Yanan Zhang, Jinming Xi, Ying Zhu,Nü Wang, Fan Xia, et al. Petal Effect:  A Superhydrophobic State with High Adhesive Force, Langmuir, 2008, 24, 4114.

4. Qiaolan Zhang, Fan Xia, et al. Wettability switching between high hydrophilicity at low pH and high hydrophobicity at high pH on surface based on pH-responsive polymer, Chem. Commun., 2008, 1199, 1199.


1. Fan Xia, Hui Ge, Yi Hou, et al. Multiresponsive surfaces change between Superhydrophilicity and Superhydrophobicity, Adv. Mater., 2007, 19, 2520.

2. Jingxia Gu, Fan Xia, et al. “Programmable delivery of hydrophilic drug using dually responsive hydrogel cages” J. Control. Release. , 2007, 117, 396.

3. Wenlong Song, Fan Xia, et al. Controllable Water Permeation on a Poly(N-isopropylacrylamide)-Modified Nanostructured Copper Mesh Film, Langmuir, 2007, 23, 327.


1. Fan Xia, Lin Feng, Shutao Wang, et al. Dual-responsive Switch Surfaces that switch between Superhydrophilicity and Superhydrophobicity, Adv. Mater., 2006, 18, 432.

2. Shutao Wang, Ying Zhu, Fan Xia, et al. The preparation of a superhydrophilic carbon film from a superhydrophobic lotus leaf, Carbon, 2006, 44, 1845.

地 址:湖北省武汉市东湖新技术开发区锦程街68号