娄筱叮 教授 博士生导师
中国地质大学（武汉）材料与化学学院
湖北省武汉市东湖新技术开发区锦程街68号
电 话：027-67885201
Email：louxiaoding@cug.edu.cn
教育经历
2007/9 - 2012/6，武汉大学，有机化学，博士，
导师：李振 教授
2004/9 - 2007/6，武汉大学，化学基地班，交流生
2003/9 - 2004/6，湖北工程学院，化学教育学，学士
工作经历
2017/1-至今，中国地质大学(武汉)，材料与化学学院，教授
2016/4-2016/10，加州大学圣塔芭芭拉分校，物理系，访问学者，合作导师：Alan J. Heeger 教授（2000年诺贝尔奖得主）
2014/11-2016/12，华中科技大学，化学与化工学院，副教授
2013/8-2014/10，华中科技大学，化学与化工学院，讲师
2012/8-2013/7，香港科技大学，高分子系，Research Associate，
合作导师：唐本忠 教授
学术成果
娄筱叮教授长期以来围绕复杂生物样本，在多功能聚集体设计及应用方面取得了创新性成果：1) 空间维度上，针对多细胞器异质性等问题，提出逐级递送多肽/聚集基元组装新策略；2) 效率维度上，针对肿瘤易转移等问题，发展多基元先共价结合再刺激分离的“一分为N”新方法；3) 时间维度上，针对不同细胞周期肿瘤标志物表达差异，开发同步后分析的端粒酶分周期提取及检测新技术。
作为第一作者或通讯作者在Chem. Soc. Rev., Acc. Chem. Res., Angew. Chem. Int. Ed., Adv. Mater., ACS Nano, Adv. Funct. Mater., Anal. Chem., Chem. Sci., Small, Biomaterials 等国际一流学术刊物发表研究论文82篇。参与主持编写英文著作“Biosensors based on sandwich assays”一部（Springer出版社）。全部论文引用近5000次，8篇论文入选ESI 1%高被引论文，H指数39。国家重点研发计划青年项目首席科学家，国家优秀青年科学基金获得者，全国青联委员，中青科协理事，湖北省杰出青年基金获得者，湖北省第十二次妇女代表，湖北省青联常委，湖北省青科协委员，中国生物材料学会影像材料与技术分会委员，《Chinese Chemical Letters》青年编委，湖北省“楚天学者计划”楚天学子。应邀在亚洲化学年会，中国化学会年会，全国分析化学年会，全国化学生物学会议，全国电化学会议，E-MRS，海峡两岸生物医学前沿交叉学术研讨会等国内外会议上做邀请报告。
承担项目与课题
1. 国家重点研发计划纳米科技专项，2020YFA0211200、微纳米尺度调控的POCT 生物传感器件在子宫内膜癌筛查中的应用研究、2021/01-2025/12、444万元、在研、主持。
2. 国家自然科学基金优秀青年基金，21722507、化学生物传感、2018/01-2020/12、130万元、结题、主持。
3. 湖北省自然科学基金杰出青年基金, 2019CFA043、光电双信号微纳米器件在肿瘤微环境单细胞分析中的应用、2019/01-2021/12、20万元、在研、主持。
4. 国家自然科学基金面上项目，21974128、模块化多肽-AIE探针对高侵袭性乳腺癌细胞中亚细胞器的长效示踪、2020/01-2023/12、63万元、在研、主持。
5. 国家自然科学基金面上项目，21574048、亲疏水可调DNA-AIE高分子复合探针的构建及其传感性能研究、2016/01-2019/12、65万元、结题、主持。
6. 国家重点研发计划重大科学仪器设备开发专项，2016YFF0100800、2017/01-2019/12、基于微流控高通量芯片的新型高灵敏传感系统开发及应用、100万元、结题、子课题负责人。
7. 浙江省自然科学基金一般项目，LY18B050002、基于多标志物联合技术的微纳米器件的构筑及其在乳腺癌早期检测中的应用、2018/01-2020/12、10万、结题、主持。
8. 国家自然科学基金青年项目，21405054、微纳米限域空间内聚集诱导发光分子的组装行为在生物/化学传感器中的应用、2015/01-2017/12、25万元、结题、主持。
9. 湖北省自然科学基金面上项目，2014CFB1012、聚集诱导发光分子在微纳米孔道中传感性能的研究、2014/01-2015/12、3万元、结题、主持。
代表性成果
1. Wu, Xia, Wu, Jun, Dai, Jun, Chen, Biao, Chen, Zhe, Wang, Shixuan, Wu, Feng, Lou, Xiaoding(*), Xia, Fan, Role of cell cycle progression on analyzing telomerase in cancer cells based on aggregation-induced emission luminogens. National Science Review 2021; DOI: 10.1093/nsr/nwaa306.
2. Yi, Xiaoqing(#), Hu, Jing-Jing(#), Dai, Jun, Lou, Xiaoding(*), Zhao, Zujin, Xia, Fan(*), Tang, Ben Zhong(*), Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy, ACS Nano, 2021, 15, 3026-3037.
3. Yang, Juliang(#), Dai, Jun(#), Wang, Quan, Cheng, Yong, Guo, Jingjing, Zhao, Zujin, Hong, Yuning, Lou, Xiaoding(*) and Xia, Fan, Tumor Triggered Disassembly of Multiple‐Agent‐Therapy Probe for Efficient Cellular Internalization, Angewandte Chemie International Edition, 2020, 59, 20405-20410.
4. Dai, Jun(#),Cheng, Yong(#),Wu, Jun(#), Wang Quan, Wang Wenwen, Yang, Juliang, Zhao, Zujin, Lou, Xiaoding(*), Xia, Fan(*), Wang, Shixuan(*), Tang, Ben Zhong, Modular peptide probe for pre/intra/postoperative therapeutic to reduce recurrence in ovarian cancer. ACS Nano 2020, 14: 14698-14714.
5. Dai, Jun(#), Li, Yinghao(#), Long, Zi, Jiang, Ruming, Zhuang, Zeyan, Wang, Zhiming, Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Efficient near-infrared photosensitizer with aggregation-induced emission for imaging-guided photodynamic therapy in multiple xenograft tumor models, ACS Nano, 2020, 14, 854-866.
6. Lou, Xiaoding(#), Huang, Yu (#), Yang, Xian, Zhu, Hai, Heng, Liping, and Xia, Fan(*), External Stimuli Responsive Liquid-Infused Surfaces Switching between Slippery and Non-slippery States: Fabrications and Applications, Advanced Functional Materials, 2020, 30, 1901130. IF= 16.836; Times Cited: 10
7. Xia, Fan, Wu, Jun, Wu, Xia, Hu, Qinyu, Dai, Jun, Lou, Xiaoding(*), Modular design of peptide- or DNA-modified AIEgens probes for biosensing applications, Accounts of Chemical Research, 2019, 52, 3064-3074.
8. Cheng, Yong(#), Sun, Chunli(#), Liu, Rui(#), Yang, Juliang, Dai, Jun, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), A multifunctional peptide-conjugated AIEgen for efficient and sequential targeted gene delivery into the nucleus, Angewandte Chemie International Edition, 2019, 58, 5049-5053.
9. Wu, Feng(#), Wu, Xia(#), Duan, Zhijuan, Huang, Yu, Lou, Xiaoding(*) and Xia, Fan(*), Biomacromolecule-Functionalized AIEgens for Advanced Biomedical Studies, Small, 2019, 1804839.
10. Lou, Xiaoding(#), Song, Yongjun(#), Liu, Rui, Cheng, Yong, Dai, Jun, Chen, Qing, Gao, Pengcheng, Zhao, Zujin and Xia, Fan (*) Enzyme and AIEgens Modulated Solid-State Nanochannels: In Situ and Noninvasive Monitoring of H2O2 Released from Living Cells, Small Methods, 2019, 1900432.
11. Hu, Rong, Chen, Bin, Wang, Zhiming, Qin, Anjun, Zhao, Zujin(*), Lou, Xiaoding(*) and Tang, Ben Zhong(*), Intriguing "chameleon" fluorescent bioprobes for the visualization of lipid droplet-lysosome interplay, Biomaterials, 2019, 203, 43-51.
12. Zhen, Shijie(#), Yi, Xiaoqing(#), Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Drug delivery micelles with efficient near-infrared photosensitizer for combined image-guided photodynamic therapy and chemotherapy of drug-resistant cancer, Biomaterials, 2019, 119330.
13. Cheng, Yong(#), Dai, Jun(#), Sun, Chunli(#), Liu, Rui, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), An intracellular H2O2-responsive AIEgen for the peroxidase-mediated selective imaging and inhibition of inflammatory cells, Angewandte Chemie International Edition, 2018, 57, 3123-3127.
14. Wang, Xudong(#), Dai, Jun(#), Min, Xuehong, Yu, Zhihua, Cheng, Yong, Huang, Kaixun, Yang, Juliang, Yi, Xiaoqing, Lou, Xiaoding (*), Xia, Fan(*), DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis, Analytical Chemistry, 2018, 90, 8162-8169.
15. Cheng, Yong, Sun, Chunli, Ou, Xiaowen, Liu, Bifeng, Lou, Xiaoding(*), and Xia, Fan(*), Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells, Chemical Science, 2017, 8, 4571-4578.
16. Zhuang, Yuan(#), Shang, Chunli(#), Lou, Xiaoding(*), Xia, Fan(*), Construction of AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity, Analytical Chemistry, 2017, 89, 2073-2079.
17. Duan, Ruixue, Lou, Xiaoding(*), Xia, Fan(*), The development of nanostructure assisted isothermal amplification in biosensors, Chemical Society Reviews, 2016, 45, 1738-1749.
18. Gao, Pengcheng, Hu, Lintong, Liu, Nannan, Yang, Zekun, Lou, Xiaoding(*), Zhai, Tianyou(*), Li, Huiqiao, Xia, Fan(*), Functional “janus” annulus in confined channels, Advanced Materials, 2016, 28, 460-465.
19. Zhuang, Yuan, Huang, Fujian, Xu, Qi, Zhang, Mengshi, Lou, Xiaoding(*), Xia, Fan, Facile, Fast-responsive and photostable imaging of telomerase activity in living cells with a fluorescence turn-on manner, Analytical Chemistry, 2016, 88, 3289-3294.
20. Jia, Yongmei(#), Gao, Pengcheng(#), Zhuang, Yuan(#), Miao, Mao, Lou, Xiaoding(*), Xia, Fan, Facile probe design: fluorescent amphiphilic nucleic acid probes without quencher providing telomerase activity Imaging inside living cells, Analytical Chemistry, 2016, 88, 6621-6626.
书籍
1. Fan Xia, Xiaojin Zhang, Xiaoding Lou, Quan Yuan, (Editors) Biosensors based on sandwich assays, Springer 2018.