李辉 教授 博士生导师
中国地质大学(武汉) 材料与化学学院
湖北省武汉市东湖新技术开发区锦程街68号
Email:lihui-chem@cug.edu.cn or li_hui@cug.edu.cn
ORCID:0000-0001-7849-9735
教育与研究经历
2014年1月-2017年8月 博士后 加州大学圣芭芭拉分校
导师:Kevin W. Plaxco教授
获瑞士国家研究基金博士后奖学金
2013年6月-2013年12月 博士后 瑞士伯尔尼大学 导师:Silvio Decurtins教授
2009年10月-2013年5月 博 士 瑞士伯尔尼大学 导师:Silvio Decurtins教授
获玛丽居里全额奖学金Marie Curie fellowship
2010年10月-2010年12月 短期访问 西班牙马德里康普顿斯大学
导师:Nazario Martin教授
2006年9月-2009年6月 硕士(保送)湘潭大学高分子化学与物理
导师:谭松庭教授
2002年9月-2006年6月 学 士 湘潭大学高分子材料与工程
学术成果
长期致力于开发和研究新型电化学生物传感器,将其应用于复杂生物体系(如血液及动物体内)的临床药物以及疾病标志物的快速、实时、有效检测,实现对疾病的早期诊断,达到早诊断早治疗的目的。迄今为止,已在J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Nanoscale, Analytical Chemistry, Macromolecules等国际核心期刊上发表SCI论文20余篇,参与撰写英文著作1部 (springer出版社),论文SCI引用400余次。申请美国发明专利两项。
获奖与荣誉
1. 瑞士自然科学基金“青年博士后奖学金”(2014-2015)
2. 欧盟“玛丽居里”奖学金(2009-2013)
参与主持的项目与课题
1. 国家自然科学基金青年基金1项,2018年-2020年,项目名称为:基于比率法的电化学生物传感器用于全血样本中小分子药物的精准、实时检测
2. 基于给受体有机半导体材料的设计,合成与应用(欧盟玛丽居里初期网络培训基金,FP7)
3. 具有实时监控,微型化,多功能化的生物传感器的研发与应用(美国NIH基金)
代表性成果
1. Hui Li, Philippe Dauphin-Ducharme, Gabriel Ortega, Kevin W. Plaxco*. Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood, J. Am. Chem. Soc., 2017, 139, 11207-11213
2. Hui Li, Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Claire Tran, Philip A. Vieira, Shaoguang Li, Christina Shin, Jacob Somerson, Tod E. Kippin, and Kevin W. Plaxco*. A biomimetic surface greatly improves the in-vivo performance of electrochemical aptamer-based sensors. Angew. Chem. Int. Ed., 2017, 56, 7492-7495
3. Hui Li, Netzahualcóyotl Arroyo-Currás, Di Kang, Francesco Riccic, and Kevin W. Plaxco*. Dual-reporter drift correction to enhance the performance of electrochemical aptamer-based sensors in whole blood. J. Am. Chem. Soc., 2016, 138, 15809-15812
4. Hui Li, Jacob Somerson, Fan Xia,* and Kevin W. Plaxco*. Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk. Anal. Chem., 2018, 90, 10641−10645.
5. Gabriel Ortega, Martin Kurnik, Philippe Dauphin‐Ducharme, Hui Li, Netzahualcóyotl Arroyo‐Currás, Amanda Caceres, Kevin W. Plaxco*, Surface Attachment Enhances the Thermodynamic Stability of Protein L. Angew. Chem. Int. Ed., 2019, 58, 1714 –1718.
6. Martin Kurnik, Gabriel Ortega, Philippe Dauphin-Ducharme, Hui Li, Amanda Caceres, Kevin W. Plaxco*. Quantitative measurements of protein-surface interaction thermodynamics; Proc. Natl. Acad. Sci. USA, 2018, 115, 8352-8357.
7. Zhihai Li, # Hui Li, # Songjie Chen, Toni Froehlich, Chenyi Yi, Christian Schönenberger, Michel Calame, Silvio Decurtins, Shi-Xia Liu*, Eric Borguet*. Regulating a Benzodifuran Single Molecule Redox Switch via Electrochemical Gating and Optimization of Molecule/Electrode Coupling, J. Am. Chem. Soc., 2014, 136, 8867-8870 (#共同一作)
8. Wenjing Hong, Hui Li, Shi-Xia Liu*, Yongchun Fu, Jianfeng Li, Veerabhadrarao Kaliginedi, Silvio Decurtins, and Thomas Wandlowski*, Trimethylsilyl-Terminated Oligo(phenylene ethynylene)s: An Approach to Single-Molecule Junctions with Covalent Au−C σ-Bonds. J. Am. Chem. Soc., 2012, 134, 19425-19431.
9. Hui Li, Peng Jiang, Chenyi Yi, Chen Li, Shi-Xia Liu*, Songting Tan*, Bin Zhao, Jörg Braun, Wolfgang Meier, Thomas Wandlowski and Silvio Decurtins, Benzodifuran-based pi-Conjugated Copolymers for Bulk Heterojunction Solar Cells. Macromolecules, 2010, 43, 8058-8062
10. An Xiang#, Hui Li#, Songjie Chen, Shi-Xia Liu*, Silvio Decurtins, Meilin Bai, Shimin Hou and Jianhui Liao*. Electronic transport in benzodifuran single-molecule transistors, Nanoscale, 2015, 7, 7665-7673 (#共同一作)
11. Hui Li, Chenyi Yi, Sofiane Moussi, Shi-Xia Liu*, Claude Daul, Michael Grätzel*, and Silvio Decurtins. Benzo[1,2-b:4,5-b’]difuran-Based Sensitizers for Dye-Sensitized Solar Cells, RSC Adv., 2013, 3, 19798-19801
12. Hui Li, Jie Ding, Songjie Chen, Christoph Beyer, Shi-Xia Liu*, Hans-Achim Wagenknecht, Andreas Hauser* and Silvio Decurtins, Synthesis, Redox and Photophysical Properties of Benzodifuran-Spiropyran Ensembles, Chem. Eur. J., 2013, 19, 6459-6466
13. Hui Li, Christina Schubert, Rubén D. Costa, Andrea La Rosa, Jürg Thüring, Shi-Xia Liu*, Chenyi Yi, Salvatore Filippone, Nazario Martín, Silvio Decurtins, Timothy Clark and Dirk M. Guldi*. Probing Charge Transfer in Benzodifuran-C60 Electron Donor-Acceptor Conjugates – Ground and Excited State Assays, ChemPhsyChem, 2013, 14, 2910-2919
14. Yves Aeschi,# Hui Li,# Zhencai Cao, Songjie Chen, Anneliese Amacher, Nathalie Bieri, Bilâl Özen, Juerg Hauser, Silvio Decurtins, Songting Tan, Shi-Xia Liu*. Directed metalation cascade to access highly functionalized thieno[2,3-f][1]benzofuran, Org. Lett., 2013, 15, 5586–5589 (#共同一作)
15. Hui Li, Peng Tang, Yan Zhao, Shi-Xia Liu*, Yves Aeschi, Lijun Deng, Jörg Braun, Bin Zhao, Yunqi Liu, Songting Tan, Wolfgang Meier, Silvio Decurtins, Benzodifuran- Containing Well-Defined pi-Conjugated Polymers for Photovoltaic Cells. J. Polym. Sci. A: Polym. Chem., 2012, 50, 2935-2943
撰写英文著作:
Hui Li*, Shaoguang Li, Fan Xia. Biosensors based on Sandwich Assays: Chapter 4- Electrochemical Sandwich Assay for protein detection, Springer, 2018, 01, 10, Page 47-68
申请美国专利两项:
1. Hui Li, Netzahualcoyotl Arroyo, Di Kang and Kevin Plaxco. Dual-Label Electrochemical Sensors with Drift Correction, PCT/US17/053228.
2. Hui Li, Philippe Dauphin-Ducharme, Gabriel Ortega, Kevin W. Plaxco. Calibration-free, drift-free electrochemical sensors employing difference in electron transfer kinetics, UCSB023P, 2017-248.